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Reproductive Specialty Center - Pioneers in Laparoscopic and Reproductive Technology
In vitro fertilization started out with the birth of baby Louise Brown in England which was followed a few years later by the first IVF birth in USA in 1983 in Norfolk, Virginia. Since that time, various refinements have occured in the stimulation of the ovaries using controlled ovarian hyperstimulation and GnRH agonists as well as in the laboratory with better handling of the gametes and enhancement to encourage fertilization and cryopreservation.
The process involves the use of Lupron daily injections seven days after ovulation followed by the start of injections with Pergonal, Metrodin, or Fertinex, Follistim, Gonal-F from the third day of the period. Frequent ultrasounds and blood estradiol assays are performed for control. At a designated time, HCG injection is administered and 34 hours later egg retrieval is performed at our office at IVF Columbia. Following egg retrieval fertilization is allowed to occur in the laboratory and two to three days later replacement of the embryo (embryo transfer) takes place at IVF Columbia. Following the transfer, progesterone injections are given on a daily basis until a pregnancy test is performed two weeks after the procedure. The oocyte retrieval is performed with the use of a mild sedative in the awake state. The majority of women do not feel pain or have any recollection of it afterwards. The embryo transfer process is identical to that of intrauterine insemination and equally painless.
Wisconsin Fertility - Home Page - IVF infertility clinic serving Madison, Middleton, with IVF, infertility, in vitro fertilization, donor egg
Robert Edwards, a Ph.D. physiologist, and Patrick Steptoe, a gynecologist, pioneered IVF in Great Britain during the 1970's. Edwards had spent the 1960's working with bits of human ovaries removed at surgery and had achieved the first fertilization of a human egg outside the body in 1967. During these same years, Steptoe was helping to develop the new surgical technique of laparoscopy. By 1971 the two men had met and begun to collaborate. Initially they retrieved eggs from the ovaries of volunteers by laparoscopy and focused on improving the timing of egg retrieval and in-vitro culture conditions. By the mid-1970's they felt ready to attempt pregnancy. Their initial pregnancy was, unfortunately, a tubal pregnancy (ectopic) in 1976. Then came true success and the first IVF baby, Louise Brown, was born in July 1978.
Wisconsin Fertility Institute
3146 Deming Way
Middleton WI 53562